A lifelong digestive disorder, found in individuals who are genetically susceptible, that results in damage to the small intestine by interfering with the absorption of nutrients. Celiac Disease (CD) is unique in that a specific food component, gluten, has been identified as the culprit. Gluten is the common name for the offending proteins in specific cereal grains that are harmful to persons with CD. These proteins are found in all forms of wheat (including durum, semolina, spelt, kamut, einkorn, and faro), and related grains, rye, barley, tritcale and possibly oats. Damage to the mucosal surface of the small intestine is caused by an immunologically toxic reaction to the ingestion of gluten.
When individuals with CD ingest gluten, the villi, tiny, hair-like projections in the small intestine that absorb nutrients from food, shrink or disappear. This is a destructive immunological reaction to gluten. Damaged villi interferes with the body's ability to absorb basic nutrients -- proteins, carbohydrates, fats, vitamins, minerals, and, in some cases, water and bile salts. If CD is left untreated, damage to the small bowel can be chronic and life threatening, causing an increased risk of associated disorders -- both nutritional and immune related.
Some long-term conditions that can result from untreated CD:
Other associated autoimmune disorders:
Less commonly linked to CD:
Many patients are asymptomatic for years, with the disease becoming active for the first time after surgery, viral infection, severe emotional stress, or pregnancy and childbirth. CD may appear at any time in the life of a person with a hereditary pre-disposition. Symptoms of CD are as varied as the nutritional deficiencies caused by the malabsorption. Infants, toddlers and children may exhibit growth failure, vomiting, bloated abdomen and behavioral changes.
Classic symptoms may include:
Dermatitis Herpetiformis (DH), is the associated skin condition characterized by blistering, intensely itchy skin. The rash has a symmetrical distribution and is most frequently found on elbows, knees and buttocks. DH patients can have gastro-intestinal damage without perceptible symptoms.
The cause of Celiac Disease, also called celiac sprue, or gluten sensitive enteropathy (GSE), is unknown. Current research indicates that CD is strongly associated with a group of genes on Chromosome 6. These genes (HLA class II antigens) are involved in the regulation of the body's immune response to the gluten protein fractions.
Who gets CD - Genetics
Celiac Disease is most commonly found in genetically susceptible Caucasians. Recent studies suggest that at least 1 in 250 persons in the United States is affected. Many cases go undiagnosed or are asymptomatic for years. CD occurs in 5 - 15 % of the offspring and siblings of the celiac. In 70% of identical twin pairs, both twins have the disease. It is suggested that family members be tested.
A person seeking preliminary diagnosis must be consuming gluten. Specific antibody blood tests are used to identify the possibility of Celiac Disease and are the initial step in screening individuals who are at risk (first-degree relatives of biopsy diagnosed celiacs). Certain antibodies are produced by the immune system in response to substances that the body perceived to be threatening, i.e. gluten. Current research shows that people with CD have higher than normal levels of these antibodies in their blood. It is recommended that patients with positive antibody tests have a small bowel biopsy to confirm the diagnosis and assess the degree of mucosal damage. Dermatitis Herpetiformis (DH) is diagnosed by a biopsy of a skin lesion and staining for IgA in the tissues. More than 85% of DH patients have small-bowel sensitivity to gluten. An experienced CD/DH pathologist is essential to establish these diagnoses. The diagnosed celiac should have medical follow-up to monitor the clinical response to the gluten-free diet. Click here for celiac screening information.
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The only treatment for CD/DH is the life-long adherence to gluten-free diet. When gluten is removed from the diet, the small intestine will start to heal and overall health improved. Medication is normally not required. Because osteopenic bone disease is common and may be profound in patients with newly diagnosed Celiac Disease, bone densomitry should be measured in adults at or shortly after diagnosis. Consult your physician regarding specific nutritional supplementation to correct any deficiencies. All patients should be monitored by their physician to ensure compliance with, and response to the gluten-free diet. Dietary compliance decreases the likelihood of osteoporosis, lymphoma and other associated illnesses.
Adapting to the gluten-free diet requires some lifestyle changes. It is crucial to read labels which are often imprecise, and learn to identify ingredients that may contain hidden gluten.
Be aware that hidden gluten can be found in some unlikely foods such as: cold cuts, soups, hard candies, soy sauce, many low or non-fat products, even licorice and jelly beans. Potential harmful ingredients include:
· unidentified starch
· modified food starch
· hydrolyzed vegetable protein-HVP
· hydrolyzed plant protein-HPP
· texturized vegetable protein-TVP
· binders, fillers, excipients, extenders
· malt & other natural flavorings